Could Claritin Cure Lyme Disease?
Excerpted from the PharmacyTimes : (02/28/2015)
An OTC allergy medication may be able to kill the bacteria behind Lyme disease, bringing researchers closer to developing the first targeted therapy for the debilitating infection.
Since Lyme-causing Borrelia burgdorferi survive on manganese (Mn), researchers from the Stanford University School of Medicine hypothesized that blocking the bacteria’s Mn transport protein, Borrelia metal transporter A (BmtA), would starve the bacteria and ultimately help cure the infection.
Among a shortlist of FDA-approved compounds that could potentially bind to the BmtA structure, the investigators determined that the antihistamine loratadine (Claritin)—and specifically its metabolite, desloratadine—were able to inhibit Mn from entering the cell walls of Borrelia, causing the bacteria to die in test tubes.
“It’s exciting to see first-hand that our insights into the metabolic activity of this elusive bacteria may give us the ability to actually kill it,” said lead study author Jayakumar Rajadas, PhD, in a press release. “…Our results bring us closer to the possibility of discovering the first targeted therapy to treat Lyme disease.”